#JEFFS BBW MODELS UPDATE#

#JEFFS BBW MODELS UPDATE#

HDSA’s Q&A on the latest huntingtin-lowering update from Ionis and Roche.First Dolly, now Piglet a new Huntington’s disease pig knock-in model confirmed.The third dimension: using minibrains to understand brain development changes in HD.Screening the entire genome for new drug targets for HD.Huntington’s disease therapeutics conference 2020 - Day 2.

HD Young Adult Study defines the sweet spot: symptom-free with measurable changes.Working as a team: Changes in brain development mean some brain regions may be slacking off.Good news from uniQure: gene therapy trial on track, and promising data in animals.Does blood hold the key to testing treatments earlier in HD patients?.Real talk: Q&A with Roche about GENERATION-HD1.“Seeing” the toxic huntingtin protein in people with HD.A spoonful of branaplam helps the huntingtin go down.

Sad news from Novartis: dosing suspended in VIBRANT-HD trial of branaplam.

Disappointing news from Novartis about branaplam and the VIBRANT-HD trial.

As well as conducting research, Jeff is a member of an HD family and himself carries the mutation which causes the disease. During his PhD he trained with Michael Hayden (UBC), his postdoctoral studies were conducted under the supervision of Marcy MacDonald (MGH, Harvard Medical School). Jeff’s PhD and postdoctoral studies all involved using mouse models to understand basic mechanisms of HD and preclinical testing of therapeutic interventions in these models. He also has an interest in gene silencing approaches to HD therapeutics, particularly using antisense oligonucleotides (ASOs). His scientific interest is in the understanding the systemic effects of Huntington’s Disease, especially metabolic changes, which he studies using a mouse “knock-in” model of Huntington’s Disease. Jeff Carroll is an Assistant Professor in the Behavioral Neuroscience Program and the Department of Psychology at Western Washington University.

Jeffs bbw models